Clinical predictive factors of pathologic complete response in locally advanced rectal cancer
نویسندگان
چکیده
منابع مشابه
Clinical predictive factors of pathologic complete response in locally advanced rectal cancer
BACKGROUND Predictive factors of pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) are still not identified. The purpose of this study was to define them. MATERIALS AND METHODS Data from consecutive LARC patients treated between January 2008 and June 2014 at our Institution were included in the analysis. All patients were tr...
متن کاملSustaining Blood Lymphocyte Count during Preoperative Chemoradiotherapy as a Predictive Marker for Pathologic Complete Response in Locally Advanced Rectal Cancer
PURPOSE The objective of this study was to explore the relationship between the circulating lymphocyte level during preoperative chemoradiotherapy (CRT) and pathologic complete response (pCR) in locally advanced rectal cancer. MATERIALS AND METHODS From May 2010 to May 2013, 52 patients treated with preoperative CRT followed by surgery, were analysed. Patients received conventional fractionat...
متن کاملOncologic impact of pathologic response on clinical outcome after preoperative chemoradiotherapy in locally advanced rectal cancer
PURPOSE Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection. METHODS We retrospectively analyzed 261 patients underwent preoperative CRT and radical resection for rectal...
متن کاملClinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer
PURPOSE The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. MATERIALS AND METHODS The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a ...
متن کاملClinical factors of post-chemoradiotherapy as valuable indicators for pathological complete response in locally advanced rectal cancer
OBJECTIVES Pathological complete response has shown a better prognosis for patients with locally advanced rectal cancer after preoperative chemoradiotherapy. However, correlations between post-chemoradiotherapy clinical factors and pathologic complete response are not well confirmed. The aim of the current study was to identify post-chemoradiotherapy clinical factors that could serve as indicat...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.8133